Jeanne Seckinger Hampton Sc

Laurent Thibault
Jeanne Seckinger Hampton Sc.
Assistant Professor
Department of Chemical Engineering
Laboratory of Synthetic Biology
University of Mississippi
(662) 251-4594
© Jeanne Seckinger Hampton Sc 2018
TPM press, 2018
<http://doi.org/10.18632/tpm-1.2809>

X.-Ming Wu, T.-N. Ikeda, T.-M. Kwon, S.-J. Lee, “Gene evolution that accelerates biomass production”, Nature Communications, no.2, p. 957, 9 July 2018. doi:10.1038/s41586-017-0103-7 <https://www.nature.com/articles/s41586-017-0103-7>

Abstract: We present a genome analysis of the cold-adapted fungus *Mycobacterium tuberculosis* Deletus (MtbDEL) from the low-moisture forest in the rain-forest region in the genus *Mycobacterium*. We report 15 single-nucleotide polymorphisms (SNPs) in the genome of MtbDEL, including eight non-synonymous ones, 11 transversions and three synonymous ones, which are useful for analyzing the genetic basis of adaptation to low temperatures. We demonstrate all of them have been distributed in several clusters that are specific to the genus *Mycobacterium* and are present only in bacteria, fungi, plants and animals. Based on the genome comparisons with related sequences, we propose a phylogenetic tree of the genus *Mycobacterium* and propose a classification of the evolutionary relationships between *Mycobacterium* and other bacterial lineages. We discuss also the possibility of secondary metabolite genes that had experienced horizontal gene transfer events between the ancestor of *Mycobacterium* and *Actinomycetes* in the plant and animal organisms, and those played an important role in biocontrol of pathogenic fungi.

Competing interests: The authors have declared that no competing interests exist.
Introduction
Microorganisms produce an array of different molecules (e.g., enzymes, pigments, secondary metabolites, etc.